Understanding how CBF-beta is involved in breast cancer spread

Project details

Researcher: Dr Paul Shore

Location: University of Manchester

Project title: Understanding how CBF-beta is involved in breast cancer spread

Key area: Secondary breast cancer

The challenge

When breast cancer spreads to the bone, it can cause severe side effects and cannot be cured. We need to find ways to stop this from happening, to improve both the chances of survival and the quality of life for people with breast cancer.

Project description

When breast cancer cells spread to other parts of the body, they have to undergo a change which allows them to move, and then maintain this new ability until they reach their destination. Dr Shore’s latest research suggests that a protein called CBF-beta (CBFβ) is responsible for maintaining the ability of breast cancer cells to be able to migrate.

In this project, Dr Shore aims to find out how CBFβ does this, which could identify ways to prevent breast cancer cells from being able to spread. As CBFβ is a protein that switches genes on and off, Dr Shore will investigate which genes are activated by CBFβ in breast cancer cells grown in the lab. Dr Shore has also shown that CBFβ could be important in allowing secondary breast tumours to grow in the bone, and will study this further in this project.

What difference will this project make?

Dr Shore’s research will help to reveal how CBFβ is involved in enabling breast cancer cells to spread to the bone. This could lead to new treatments to stop this from happening, which would greatly improve the chances of survival and quality of life for women and men with breast cancer.

Dr Shore featured in the BBC Lifeline Appeal on behalf of Breast Cancer Now

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