Studying a group of genes involved with aggressive types of breast cancer

Dr Anguraj Sadanandam (centre) with his team

Project details

Researcher: Dr Anguraj Sadanandam

Location: The Institute of Cancer Research, London

Project title: Studying a group of genes involved with aggressive types of breast cancer

Key area: Treatment

The challenge

Some types of breast cancer, such as triple negative breast cancer, can be more aggressive, and lack treatment options that are available for other types of the disease. We need to find new ways to treat aggressive forms of breast cancer to improve survival for people with these types of cancer.

Project description

Triple negative breast cancer is a type of the disease which can be more aggressive. Researchers are further categorising triple negative breast cancer into more subtypes to find the best way to treat different people with the disease. Two of these subtypes of triple negative breast cancer are called basal-like and claudin-low breast cancer.

Dr Sadanandam has found a group of genes which are overactivated in basal like and claudin-low breast cancer, which he will study further in this project. He will first measure the activation of these genes in samples of tumours donated by patients, some of which will be obtained from our Breast Cancer Tissue Bank. He will also study what these genes do in breast cancer cells from these aggressive subtypes that have been grown in the lab, or implanted into mice.

Finally he will test whether new drugs could make an effective treatment for basal-like and claudin-low breast cancer.

What difference will this project make?

Dr Sadanandam aims to understand the role of a group of genes in two aggressive subtypes of triple negative breast cancer. His work could eventually lead to new ways to treat these types of breast cancer and improve chances of survival for people with the disease.

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