Professor David French would like to understand whether for women at low risk of breast cancer, the benefits of screening outweigh the potential harms, and if so, whether these women should be offered less frequent screening appointments.

Professor Kaye Williams is investigating whether blocking two proteins simultaneously could reduce the growth and spread of breast cancer. The hope is that her work could bring new treatments to people with aggressive forms of the disease, and in doing so save lives.

Having a mutation in BRCA1 can increase a person’s risk of developing breast cancer. LYN kinase is switched on in cells where BRCA1 is mutated. Professor Smalley will investigate whether this protein could be targeted to treat and prevent breast cancer.

Breast cancer can trick our immune system into ignoring it, which can cause cancer cells to grow and spread. Professor Damian Mole’s team is studying one possible way tumours do this, so we can develop new treatments to improve the chances of survival for people with breast cancer.

In the future, breast screening could be adapted to a woman’s personal risk of developing breast cancer, which could change how regularly women are screened. Dr Jo Waller will investigate the concerns women have about this to ensure these approaches are effective.

Professor Andrew Evans is investigating whether measuring breast density using mammograms can be an effective way to tell if hormone therapy is working to stop breast cancer from returning, as early as possible.