Professor Kristijan Ramadan is hoping to understand why some breast cancers become resistant to a breast cancer treatment called PARP inhibitors, and is looking for new ways to overcome this resistance.
Dr Jason Carroll is investigating what role the gene ARID1A plays in breast cancer spreading around the body. He also aims to understand if a class of drugs called BET inhibitors could be used to treat secondary breast cancer that has changes in this gene.
Professor Kaye Williams is investigating whether blocking two proteins simultaneously could reduce the growth and spread of breast cancer. The hope is that her work could bring new treatments to people with aggressive forms of the disease, and in doing so save lives.
Dr Seth Coffelt is investigating how a specific type of white blood cell can help breast cancer to spread throughout the body. His work could lead to new ways to prevent the spread of breast cancer, and ultimately stop people dying from the disease.
Breast cancer that has spread to the brain can be particularly hard to treat and severely affects people’s quality of life. Walk the Walk Fellow Dr Damir Varešlija is looking at how gene switches in breast cancer cells might make them more likely to spread to the brain and hopes to find ways to stop this from happening.
Dr Stephen Robinson would like to test if manipulating friendly gut bacteria can influence the immune system and in turn make it harder for breast cancer to spread around the body and become incurable.