Dr Nick Orr is working to understand how some genetic changes linked to an increased risk of breast cancer in men and women, may cause the disease. This could help us develop new ways to prevent and treat breast cancer.

Dr Sacha Howell would like to understand if breast cancers arising due to alterations in the BRCA1 gene could be prevented by using an existing drug in a new context.

Dr Adam Brentnall hopes to find a better way to identify who has a higher risk of developing breast cancer and the type of breast cancer they may develop.

In the future, breast screening could be adapted to a woman’s personal risk of developing breast cancer, which could change how regularly women are screened. Dr Jo Waller will investigate the concerns women have about this to ensure these approaches are effective.

We know that our genetics play a key role in determining breast cancer risk, but we need to know much more about the specific genes involved and how they affect an individual person’s risk.