Dr Adam Brentnall hopes to find a better way to identify who has a higher risk of developing breast cancer and the type of breast cancer they may develop.

Professor David French would like to understand whether for women at low risk of breast cancer, the benefits of screening outweigh the potential harms, and if so, whether these women should be offered less frequent screening appointments.

Having a mutation in BRCA1 can increase a person’s risk of developing breast cancer. LYN kinase is switched on in cells where BRCA1 is mutated. Professor Smalley will investigate whether this protein could be targeted to treat and prevent breast cancer.

In the future, breast screening could be adapted to a woman’s personal risk of developing breast cancer, which could change how regularly women are screened. Dr Jo Waller will investigate the concerns women have about this to ensure these approaches are effective.

Dr Nora Pashayan would like to find the best way to personalise the breast screening programme, adjusting screening timing and frequency according to a woman’s individual risk, in order to maximise the benefits and minimise the potential harms of screening.

We know that our genetics play a key role in determining breast cancer risk, but we need to know much more about the specific genes involved and how they affect an individual person’s risk.