Dr John Maher is developing a new type of immunotherapy for breast cancer. In this project he is improving a CAR-T cell therapy so that it’s effective against breast cancer cells but doesn’t attack non-cancer cells, ensuring that the treatment is safe for testing in patients.

We need better ways to track how secondary tumours in the bone respond to treatments. Professor Gary Cook is investigating whether a ‘tracer’ molecule can tell if these treatments are working at an earlier stage than is currently possible – and help patients live well for longer.

Professor Christopher Scott and his PhD student would like to evaluate whether blocking a protein called cathepsin S (CTSS) can prevent triple negative breast cancer from spreading and forming incurable secondary tumours.

Professor Gerry Humphris will develop a new intervention to improve communication between radiographers and patients. This will ensure that patients’ anxieties are being addressed and reduce their fear that the cancer will return, improving their quality of life.

 

Professor Karen Blyth is studying why RUNX1 protects against ER-positive breast cancer but promotes the development of other types of the disease. Her research could ultimately lead to smarter treatments that improve the chances of survival for people with breast cancer.

 

https://breastcancernow.org/donatePeople with ER positive breast cancer can be prescribed anti-hormone treatment for five years or more to reduce the risk of recurrence, but many find it hard to complete the course. Dr Hughes’ team are developing a way to help people persist with their treatment.