Bosutinib is a drug that has been tested in breast cancer before but only worked for some patients. Professor Valerie Brunton’s team are trying to identify who are most likely to benefit from bosutinib, to bring new treatment options to those who need them.     

Professor Claire Lewis and her team are studying how the immune system can be used to destroy triple negative breast cancer. They are investigating whether a new combination of drugs, including avelumab, can boost the immune system’s response to a tumour.

Professor Bryan Hennessy, Dr Alex Eustace and colleagues are studying a drug gedatolisib, to understand which breast cancers are most susceptible to this treatment. Ultimately their research could improve the chances of survival for people with breast cancer.

New ways to treat breast cancer that has spread to the bones are urgently needed. Professor Ingunn Holen is investigating the effect of the drug palbociclib on the spread of breast cancer to bone. She aims to find new treatment combinations to improve options available for patients.  

Dr Seth Coffelt wants to see how a type of immune cell, called gamma delta T cell, works and whether it could be used to treat triple negative breast cancer.

Dr Leo Carlin, along with Dr Seth Coffelt and Dr Frederic Fercoq, wants to understand how breast cancer cells manipulate the immune systemin the lung. He is hoping to use the results of this research to improve immunotherapy treatment for breast cancer.