Breast cancer stem cells are likely to be the reason why some breast cancers manage to avoid treatment, come back and spread. Dr Ucar aims to investigate whether stopping two proteins from working in breast cancer stem cells could offer a way to target and destroy the cells.


When breast cancer spreads it becomes incurable, and can cause debilitating side-effects. Professor Nicola Sibson hopes to find better treatment combinations to control secondary breast tumours in the brain, to improve the quality of life and chances of survival for patients.


Professor Lewis will investigate whether targeting two molecules, CXCR4 and VEGFA, can prevent relapse and the development of secondary tumours in triple negative breast cancer.


Dr Georgia Mavria is studying how a molecule called DOCK4 is involved in the spread of breast cancer to the brain. Her work could lead to new ways to prevent secondary tumours from growing in the brain and ultimately save lives.


Breast tumours can sometimes become resistant to treatment. Dr Yinyin Yuan will find out how the non-cancer cells that surround tumours help them develop resistance to avoid this. 


Professor Robert Clarke is studying how a molecule called IL 1β helps breast cancer spread to the bones.