Dr Crescens Tiu is developing treatments that can overcome breast cancer’s ability to hide from the immune system. This could lead to more effective ways to treat breast cancer.

Professor Leonie Young is working to determine whether some secondary breast cancers that have spread to the brain could be treated with drugs called PARP inhibitors. She hopes that more people could benefit from this type of treatment.

Professor Greg Hannon will investigate the difference between breast cancer cells that are resistant to certain drugs and those that are not. He hopes to find ways to improve treatments so that more people with breast cancer live, and live well.

Dr Helfrid Hochegger is working to understand a new drug target in cancer cells that could be used together with palbociclib to treat triple negative breast cancer. This could provide a new treatment that could help more people with triple negative breast cancer survive.

Dr Rachael Natrajan is working to understand the role of a protein called SF3B1 in oestrogen receptor positive (ER+) breast cancer. She wants to find better ways to treat people whose breast cancer has changes to this protein.

Professor Janet Brown wants to determine if combining an immunotherapy drug avelumab with another drug, radium-233, could make the treatment more effective. She hopes this combination will improve the immune response to secondary breast cancer in the bone and at other sites in the body.