Professor Nicholas Turner and Dr Alicia Okines will lead a clinical trial of the drug crizotinib for patients with lobular breast cancer that has spread to other parts of the body. This trial, called the ROLO study, could lead to a much-needed new treatment for this type of breast cancer.

Dr Boyne will investigate whether the increased risk of secondary breast cancer in patients with type-two diabetes is caused by ‘molecular messages’ carried in fragments of blood cells known as platelets.

Breast cancer stem cells are likely to be the reason why some breast cancers manage to avoid treatment, come back and spread. Dr Ucar aims to investigate whether stopping two proteins from working in breast cancer stem cells could offer a way to target and destroy the cells.

 

When breast cancer spreads it becomes incurable, and can cause debilitating side-effects. Professor Nicola Sibson hopes to find better treatment combinations to control secondary breast tumours in the brain, to improve the quality of life and chances of survival for patients.

 

Professor Lewis will investigate whether targeting two molecules, CXCR4 and VEGFA, can prevent relapse and the development of secondary tumours in triple negative breast cancer.

 

Dr Georgia Mavria is studying how a molecule called DOCK4 is involved in the spread of breast cancer to the brain. Her work could lead to new ways to prevent secondary tumours from growing in the brain and ultimately save lives.