Miss Karina Cox is investigating whether a special ultrasound method can help specialists find out if breast cancer has spread to the lymph nodes in the armpit.

Dr Jason Carroll is investigating what role the gene ARID1A plays in breast cancer spreading around the body. He also aims to understand if a class of drugs called BET inhibitors could be used to treat secondary breast cancer that has changes in this gene.

There are currently few targeted treatments available for triple negative breast cancer. In addition, it can be more aggressive than other breast cancers. We need to understand what makes triple negative breast cancer different from other forms of the disease to develop new effective targeted treatments for patients.

Professor David French would like to understand whether for women at low risk of breast cancer, the benefits of screening outweigh the potential harms, and if so, whether these women should be offered less frequent screening appointments.

Professor Kaye Williams is investigating whether blocking two proteins simultaneously could reduce the growth and spread of breast cancer. The hope is that her work could bring new treatments to people with aggressive forms of the disease, and in doing so save lives.

Having a mutation in BRCA1 can increase a person’s risk of developing breast cancer. LYN kinase is switched on in cells where BRCA1 is mutated. Professor Smalley will investigate whether this protein could be targeted to treat and prevent breast cancer.