Breast cancer stem cells are thought to be responsible for some breast cancers developing resistance to treatment, and may cause breast cancer to spread. Dr Paloma Garcia wants to find out more about how we can target these cells to stop breast cancer spreading.

Miss Karina Cox is investigating whether a special ultrasound method can help specialists find out if breast cancer has spread to the lymph nodes in the armpit.

Dr Jason Carroll is investigating what role the gene ARID1A plays in breast cancer spreading around the body. He also aims to understand if a class of drugs called BET inhibitors could be used to treat secondary breast cancer that has changes in this gene.

There are currently few targeted treatments available for triple negative breast cancer. In addition, it can be more aggressive than other breast cancers. We need to understand what makes triple negative breast cancer different from other forms of the disease to develop new effective targeted treatments for patients.

Professor David French would like to understand whether for women at low risk of breast cancer, the benefits of screening outweigh the potential harms, and if so, whether these women should be offered less frequent screening appointments.

Professor Kaye Williams is investigating whether blocking two proteins simultaneously could reduce the growth and spread of breast cancer. The hope is that her work could bring new treatments to people with aggressive forms of the disease, and in doing so save lives.