These definitions may help you feel better informed, whether you've been diagnosed with breast cancer or know someone who has.
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Ablation Removal of or stopping a part of the body from working by surgery, hormone therapy or radiotherapy.
Abraxane A chemotherapy drug used to treat breast cancer.
AC chemotherapy A combination of the chemotherapy drugs Adriamycin (also known as doxorubicin) and cyclophosphamide.
Adjuvant Treatment given after initial treatment, for example chemotherapy or radiotherapy given after surgery.
Adriamycin see Doxorubicin
Advanced breast cancer Breast cancer that has spread beyond the breast and the lymph nodes under the arm to other parts of the body. Also known as secondary, stage 4 or metastatic breast cancer.
Adverse effect An undesired or harmful effect of a treatment.
Alopecia Loss of hair from the head or body.
Alternative therapy Term used to describe therapies used by some people in place of standard medical treatment.
Anaemia Too few red blood cells in the body. It may cause symptoms including tiredness, shortness of breath and weakness.
Anthracyclines A group of chemotherapy drugs commonly used to treat breast cancer. Examples include doxorubicin (also known as Adriamycin) and epirubicin.
Anti-emetics Drugs used to reduce nausea (feeling sick) and vomiting (being sick).
Areola Coloured area of skin around the nipple.
Arimidex A brand name for Anastrozole
Aromasin A brand name for Exemestane
Aromatase inhibitors Breast cancer treatment that works by reducing the amount of oestrogen in the body. A type of hormone (endocrine) therapy.
Ascites A build-up of fluid between the two layers of the peritoneum (a membrane that forms the lining of the abdomen).
Avastin see Bevacizumab
Axilla Under the arm, the armpit.
Axillary clearance An operation to remove all the lymph nodes (also called lymph glands) from under the arm (axilla).
Axillary nodes The lymph nodes (also called lymph glands) under the arm (axilla).
Axillary sampling An operation to remove some of the lymph nodes (also called lymph glands) from under the arm (axilla).
Benign Not cancer.
Bilateral Affecting or about both the right and left sides of body. For example, a bilateral mastectomy is removal of both breasts.
Biological therapies see Targeted therapies
Biopsy Removal of tissue to be looked at under a microscope.
Biosimilars Drugs that are very similar, but not identical, copies of biological therapies.
Bisphosphonates A group of drugs for:
- Reducing the risk of breast cancer coming back in post-menopausal women
- Treating secondary breast cancer in the bone
- Preventing or treating osteoporosis
Examples of bisphosphonates include sodium clodronate, zolendronic acid and ibandronic acid.
Blood cells Tiny structures produced in bone marrow. Includes red blood cells, white blood cells and platelets.
Blood count The numbers of red and white blood cells and platelets in a sample of blood.
Bone marrow Spongy material found in the centre of bones where red and white blood cells and platelets are made.
Bone metastases Also known as secondary breast cancer in the bone. Cancer that has spread from the breast to the bones.
Bone scan A test to help identify any abnormal changes, such as tumours, infection or fractures, in the bones.
Brain metastases Also known as secondary breast cancer in the brain. Cancer that has spread from the breast to the brain.
BRCA1 and BRCA2 People who inherit an altered BRCA1 or BRCA2 gene from either parent have a much higher risk of developing breast cancer and some other cancers compared with the general population.
Breast calcification Areas of calcium deposit in one or both of the breasts.
Breast care nurse Provides information and support to people diagnosed with breast cancer.
Breast-conserving surgery Also known as wide local excision or lumpectomy. The removal of the cancer with a margin (border) of normal breast tissue around it.
Breast density refers to the amount of fibrous and glandular tissue compared with fatty tissue in the breast. A woman has high breast density when there is more collagen and glandular tissue compared to fatty tissue in her breasts, and low breast density when there is more fatty tissue compared to glandular tissue and collagen.
Breast reconstruction Surgery to rebuild a breast after a tumour is removed.
Breasts Made up of lobules (milk-producing glands) and ducts (tubes that carry milk to the nipple). These are surrounded by tissue that gives breasts their size and shape.
Cannula A small plastic tube through which drugs are given into a vein, usually in the arm or hand.
Carboplatin A chemotherapy drug used to treat breast cancer.
Carcinoma Another word for cancer.
Cardiotoxicity Damage to the heart muscle causing the heart to become weaker and less efficient in pumping. Caused by some chemotherapy and targeted therapy drugs.
CDK inhibitors A group of targeted therapies including abemaciclib, palbociclib and ribociclib, often used alongside hormone therapies.
Cell proliferation An increase in the number of cells as a result of them multiplying and growing.
Cells The tiny structures that make up the tissues of the body.
Cellulitis An infection of the skin and tissue beneath the skin. People who have lymphoedema have an increased risk of cellulitis in the arm or chest area.
Chemoprevention A way to reduce the risk of a disease by taking medication. The drugs tamoxifen and raloxifene are available on the NHS for some women with an increased risk of developing breast cancer.
Chemotherapy Treatment aimed at destroying cancer cells using anti-cancer drugs.
Chest wall The muscles, bones and joints that make up the area of the body between the neck and the abdomen (belly).
Chronic A term used to describe an illness, disease or condition that is long lasting and generally slow to progress.
CISH (chromogenic in situ hybridization) A test for measuring HER2 levels in cancer cells.
Cisplatin A chemotherapy drug used to treat breast cancer.
Clinical trials Research that aims to improve treatment or care for patients.
CMF A combination of three chemotherapy drugs – cyclophosphamide, methotrexate and 5-fluorouracil (5FU).
Cognitive impairment Difficulty concentrating or being more forgetful as a result of a cancer diagnosis or treatment. Sometimes called ‘chemo brain’ or ‘chemo fog’.
Complementary therapies A varied group of therapies, such as massage and acupuncture, used alongside conventional medical treatments.
Cording (also known as axillary web syndrome) Tight ‘cords’ of tissue stretching down the inside of the arm, which can occur after surgery to remove lymph nodes under the arm. Causes pain and restricts arm movement. Sometimes cords can be felt in the chest area too.
Core biopsy Biopsy using a hollow needle to take one or more samples of tissue for analysis under a microscope.
CyberKnife see Stereotactic radiotherapy
Cyclophosphomide A chemotherapy drug used to treat breast cancer.
DCIS (ductal carcinoma in situ) An early type of breast cancer where the cells have not yet developed the ability to spread out of the ducts into surrounding breast tissue or to other parts of the body. Sometimes called pre-invasive, intraductal or non-invasive cancer.
D-DISH (dual-color dual-hapten brightfield in situ hybridization) A test for measuring HER2 levels in cancer cells.
Denosumab (Prolia) A targeted therapy used to treat osteoporosis.
Denosumab (Xgeva) A targeted therapy used to treat the effects of secondary breast cancer in the bone.
DEXA (dual energy x-ray absorptiometry) scan A scan that measures bone mineral density. Used to diagnose or monitor osteoporosis, or assess the risk of developing it.
Diagnostic radiographer Someone trained to carry out x-rays and scans.
DIEP (deep inferior epigastic perforator) flap A type of breast reconstruction that uses the skin and fat between the belly button and the groin.
Differentiation A term used in pathology results, comparing the cancer cells to normal cells. Well-differentiated cancer cells look almost normal (a similar size and shape to normal cells); moderately differentiated cancer cells look less like normal cells (often larger and more varied shapes); poorly differentiated cancer cells look most changed and are usually fast growing.
Drug resistance The ability of cancer cells to resist the effects of a drug.
ECHO (echocardiogram) A type of ultrasound of the heart, to check how well it is working.
EC-T A combination of the chemotherapy drugs epirubicin, cyclophosphamide and Taxol (paclitaxel) or sometimes Taxotere (docetaxel).
EGFR (epidermal growth factor receptor) A type of protein found on the surface of cells. When there are higher than normal levels (known as over-expression) on cancer cells, they help the cancer to grow.
Embolism When blood flow is blocked, usually by a blood clot or air bubble.
Encapsulated Surrounded and encased. For example, an encapsulated breast implant has been encased by a build-up of dense, tough tissue, also called fibrous tissue.
Endocrine therapy see Hormone therapy
Endometrial cancer Cancer of the lining of the womb (uterus).
Epirubicin A chemotherapy drug used to treat breast cancer.
Eribulin A chemotherapy drug used to treat breast cancer. Its brand name is Halaven.
ER status ER positive (ER+) means the breast cancer has oestrogen receptors. ER negative (ER-) means the breast cancer doesn’t have oestrogen receptors (see Oestrogen receptors)
Everolimus A targeted therapy used to treat secondary breast cancer. Its brand name is Afinitor.
Excision Surgical removal.
Expander implant A type of breast implant used in breast reconstruction. The implant is gradually inflated with saline (salt water) through a small port.
Faslodex see Fulvestrant
FEC A combination of the chemotherapy drugs 5-flurouracil (5FU), epirubicin and cyclophosphamide.
FEC-T A combination of the chemotherapy drugs 5-flurouracil (5FU), epirubicin, cyclophosphamide and Taxotere (docetaxel).
Femara see Letrozole
Fibrocystic A benign (not cancer) breast condition when multiple cysts or lumpy areas develop in one or both breasts.
Fine needle aspiration (FNA) Using a fine needle and syringe to take a sample of cells for analysis under a microscope.
FISH (fluorescence in situ hybridisation) A test for measuring HER2 levels in cancer cells. FISH negative (FISH-) means normal levels are present, FISH positive (FISH+) means excessive amounts are present, classed as HER2+.
Fluorouracil A chemotherapy drug used to treat breast cancer. Its brand name is 5FU.
Fraction Each radiotherapy treatment is known as a fraction. Treatment involves several fractions given over a few days or weeks.
Gamma knife see Stereotactic radiotherapy
Gemzar see Gemcitabine
Gene Stores the biological information we inherit from our parents, affecting the way we look and how our bodies work and grow.
Grade The system used to classify cancer cells according to how different they are to normal breast cells and how quickly they are growing.
HER2 (human epidermal growth factor receptor 2) A protein involved in the growth of cells. Around 15–20 per cent of breast cancers have higher than normal levels of HER2 (known as HER2 positive) which helps the cancer to grow.
Herceptin see Trastuzumab
Hereditary Characteristics, conditions or illnesses that can be passed from a parent to their child through genes.
Hickman line Also known as a skin-tunnelled catheter. A fine silicone tube through which chemotherapy drugs are given. It’s put into a large vein through a small cut in the chest wall, and can stay in place for several months.
Hormone therapy (also called endocrine therapy) Drugs that work in different ways to block the effect of oestrogen on cancer cells. Only used if the breast cancer is hormone receptor positive.
Hormones Chemical messengers produced in various organs of the body that control growth and reproduction.
HRT (hormone replacement therapy) A treatment containing female sex hormones – either oestrogen alone or a combination of oestrogen and progesterone – to help reduce menopausal symptoms.
Hypercalcaemia Higher than normal levels of calcium in the blood. Can be caused by secondary breast cancer in the bones.
Hyperplasia An increase in the number and growth of cells.
Hypocalcaemia Lower than normal levels of calcium in the blood.
IHC (immunohistochemistry) A test for measuring HER2 levels in cancer cells. A score of 0 or 1+ means the breast cancer is HER2 negative. A score of 2+ is borderline and a score of 3+ means the breast cancer is HER2 positive.
Imaging Techniques, including mammography, that allow doctors to get a detailed picture of internal body structures.
Immune response An automatic defence function of the body that recognises and protects it from infection and foreign bodies, for example.
Immunosuppression Reduced ability of the body to protect against infection and disease. Can be caused by chemotherapy.
Immunotherapy A type of targeted therapy that uses the body’s immune system to help it fight cancer.
Incidence Refers to how many people are diagnosed with a disease per year. It can be expressed as a number or as a rate, for example the number of people diagnosed per 100,000 of a population.
In situ (breast cancer) Breast cancer that has not developed the ability to spread outside the ducts, either within the breast or elsewhere in the body.
Infertility Being unable to get pregnant. May be temporary or permanent and can be caused by chemotherapy, for example.
Inflammation Swelling, redness or warmth caused by the reaction of body tissues to injury, infection or irritation.
Inflammatory breast cancer A rare type of breast cancer where the skin of the breast looks red, and may feel warm and tender (‘inflamed’).
Infusion A method of delivering fluids or drugs, usually into a vein.
Intraductal see DCIS
Intramuscular (IM) Injected into a muscle.
Intravenous (IV) Injected into a vein.
Invasive cancer Cancer that has the potential to spread to other parts of the body.
Ipsilateral On the same side, as opposed to contralateral.
Kadcyla see Trastuzumab emtansine
Ki67 A protein found in cells. The higher the levels, the faster the cells are dividing and growing.
LD (latissimus dorsi) flap A type of breast reconstruction that uses the latissimus dorsi (a large muscle in the back just below the shoulder blade), along with skin and fat.
Local recurrence see Recurrence
Local treatment Specific to an area of the body, for example surgery or radiotherapy.
Locally advanced breast cancer (LABC) Breast cancer that has spread to the chest wall or skin of the breast, or the lymph nodes around the chest, neck and under the breast bone, but has not spread to other areas of the body.
Lumpectomy An operation to remove an area of breast tissue. In breast cancer may also be called wide local excision or breast-conserving surgery.
Lymph nodes Also known as lymph glands. Small oval-shaped structures found in clusters throughout the lymphatic system, for example under the arm (axilla).
Lymphatic system The drainage and filtering system of the body, made up of lymph nodes (lymph glands), vessels and fluid. Helps to get rid of waste and fight infection.
Lympho-vascular invasion When breast cancer cells invade (spread into) the lymph and blood vessels within the breast, and can be seen in these vessels under the microscope.
Lymphoedema Swelling of the arm, hand, chest or breast area caused by a build-up of lymph fluid in the surface tissues of the body. It can occur as a result of damage to the lymphatic system, for example because of surgery or radiotherapy to the lymph nodes under the arm and surrounding area.
Malignant Cancer (abnormal cells that divide and grow in an uncontrolled way).
Mammogram A breast x-ray.
Mastectomy This is a type of surgery in which all of the breast tissue is removed, including the nipple.
Metastases Another name for secondary breast cancer.
Methotrexate A chemotherapy drug used to treat breast cancer.
Mets Short for metastases.
Microcalcifications Small deposits of calcium in the breast. They show up as white dots on a mammogram, and are sometimes a sign of DCIS (ductal carcinoma in situ).
MUGA (multiple-gated acquisition) A scan using a small amount of radioactive material, to check how well the heart is working.
Multi-centric When there is more than one area of breast cancer in different quarters of the breast.
Multi-focal When there is more than one area of breast cancer but only in one quarter of the breast.
Navelbine see Vinorelbine
Neo-adjuvant Treatment given before surgery. Examples are chemotherapy and hormone therapy. Sometimes called primary, for example primary hormone therapy.
Neupogen A type of GCSF
Neutropenia When the number of white blood cells falls below a certain level. This may happen as a side effect of chemotherapy. If there is also a high temperature (above 38°C), it’s known as febrile neutropenia.
Occult breast cancer Breast cancer that can’t be felt or seen on imaging (for example, mammogram or ultrasound). It’s usually diagnosed when someone is being investigated for symptoms elsewhere in the body, for example enlarged lymph nodes. Sometimes a biopsy in another part of the body shows cells that look like secondary breast cancer cells, indicating there is a primary cancer in the breast, even though it can’t be seen.
Oligometastatic disease Small, isolated areas of secondary breast cancer that are stable (not progressing) and usually present in only one place in the body (oligo means ‘little' or 'few’).
Oncologist A doctor who specialises in cancer (oncology). A medical oncologist specialises in cancer drugs. A clinical oncologist specialises in radiotherapy alone or radiotherapy and cancer drugs.
Oncoplastic surgeon A breast cancer surgeon with training in plastic surgery.
OSNA (one step nucleic acid amplification) A test used during surgery to see if breast cancer cells are in the lymph nodes under the arm.
Osteopenia Decreased bone mineral density (a measurement of bone strength) but not low enough to be diagnosed as osteoporosis.
Osteoporosis Literally means 'porous bones'. Decreased bone mineral density (a measurement of bone strength), meaning thinner, weaker bones that are more likely to break. It’s usually diagnosed with a bone density scan (often called a DEXA scan).
Ovarian suppression Sometimes called ovarian ablation. Stopping the ovaries producing oestrogen using surgery, drugs or radiotherapy.
Palbociclib A targeted therapy used to treat secondary breast cancer. Its brand name is Ibrance.
Palliative care Focuses on symptom control and support when cancer cannot be cured. Usually involves a team of healthcare professionals such as specialist nurses, doctors, social workers and physiotherapists.
Palliative care consultant A doctor who specialises in palliative care.
Palliative care nurse A nurse specially trained to provide palliative care.
Palliative treatment Aims to control symptoms and slow down the progress of cancer, rather than cure it.
PARP inhibitors PARP stands for poly-ADP ribose polymerase. It’s a protein that helps cells repair themselves if they become damaged. PARP inhibitors stop the PARP from repairing cancer cells.
Pathology The branch of medicine that looks at how disease affects the body’s cells and tissues. Each time you have tissue removed a report is written by a pathologist (a doctor who examines the tissue).
Peripherally inserted central catheter (PICC) A tube put into a vein in the arm through which chemotherapy drugs are given. It stays in place throughout the course of treatment.
Perjeta see Pertuzumab
Plastic surgeon A specialist surgeon trained in plastic surgery techniques such as breast reconstruction.
Portacath Also called an implanted port. A thin, soft, hollow tube made of plastic that’s put into a vein. The tube is attached to a rubber disc (port). Drugs are given into the port which is usually placed under the skin on the chest.
Primary breast cancer Breast cancer that has not spread beyond the breast or the lymph nodes (lymph glands) under the arm (axilla).
Progression The growth and spread of a disease such as breast cancer.
Progesterone A naturally occurring female hormone. It is essential for normal sexual development and the functioning of female reproductive organs.
Progesterone receptors Proteins within cancer cells that attach to the hormone progesterone (may be abbreviated to PR).
Prognosis The outlook of a disease, such as the likelihood of it coming back (recurrence) and the person’s life expectancy.
Prosthesis An artificial breast form used to restore shape when all or part of the breast has been removed.
Quality of life A term often used by healthcare professionals and researchers to refer to the well-being of patients during and after their breast cancer treatment. Quality of life can be affected by any of the experiences a patient has from diagnosis through to surviving breast cancer, including the physical, psychological and social implications of the disease and its treatment.
Radiotherapy The use of high energy x-rays to destroy cancer cells.
Reconstruction Surgery that rebuilds the breast shape after all or part of the breast has been removed.
- Local recurrence Breast cancer that has come back in the chest/breast area or in the skin near the original site or scar.
- Locally advanced breast cancer (sometimes called regional recurrence) Breast cancer that has come back and has spread to the chest wall or skin of the breast, or the lymph nodes around the chest, neck and under the breast bone, but has not spread to other areas of the body. Sometimes breast cancer is locally advanced when it is first diagnosed. People who have locally advanced breast cancer are thought to have an increased risk of cancer cells spreading to other areas of the body compared to those with stage 1 or 2 breast cancers.
- Distant recurrence Also called metastatic, advanced, stage 4 or secondary breast cancer. When cancer has spread from the breast to other parts of the body such as the bones, lungs, liver or brain.
Remission When the signs and symptoms of a disease partly or completely disappear. It may be temporary or permanent.
Ribociclib A targeted therapy used to treat secondary breast cancer. Its brand name is Kisqali.
Risk factor Something that increases a person’s chance of developing an illness such as cancer.
Saline implant A type of breast implant that contains a sterile liquid solution (saline). Used in breast reconstruction.
Secondary breast cancer Breast cancer that has spread to other parts of the body such as the bones, lungs, liver or brain. Also called metastases, advanced breast cancer, secondaries or stage 4 breast cancer.
Selective internal radiation therapy (SIRT) A type of targeted internal radiotherapy that uses radioactive beads to deliver radiation to the cancer.
Sentinel lymph node biopsy (SLNB) Identifies whether the sentinel lymph node (the first lymph node that the cancer cells are most likely to spread to) is clear of cancer cells. Sometimes called sentinel node biopsy (SNB).
Seroma A collection of fluid that forms under a wound after an operation. It is a common and sometimes uncomfortable but harmless effect of breast surgery.
SGAP (super gluteal artery perforator) flap and IGAP (inferior gluteal artery perforator) flap Types of breast reconstruction that use fat and skin taken from the upper or lower buttock.
Side effect Unwanted effect of treatment.
Silicone implant A type of breast implant filled with silicone gel. Used in breast reconstruction.
Spinal cord compression Pressure on the spinal cord and nerves. It can be caused by the cancer growing in, or spreading into, the bones of the spine and can result in permanent damage to the spinal cord.
Stable disease The cancer has stayed the same size or has grown only a little.
Stereotactic core biopsy Taking a sample of tissue using a needle biopsy device connected to a mammogram machine and linked to a computer. Helps locate the exact position of the area to be biopsied.
Steroids May be given as part of cancer treatment, for example to help with side effects of chemotherapy such as nausea and vomiting, or to control some symptoms caused by cancer.
Subcutaneous injection An injection into the fatty tissue under the skin.
Supportive care see Palliative care
Surgical margin How close the cancer cells are to the edges of the whole area of tissue removed during surgery.
Systemic treatment Drugs that treat the whole body, for example chemotherapy, hormone therapy and targeted therapy.
Tamoxifen A hormone therapy drug used to treat breast cancer.
Taxol see Paclitaxel
Taxotere see Docetaxel
TENS machine A small portable device that uses adhesive skin pads to deliver small electrical impulses to help relieve pain.
Terminal A term often used when someone is approaching the last few weeks or days of life.
Thrombosis Occurs when blood forms a clot. If the clot occurs in a major vein, the condition is known as a deep vein thrombosis or DVT.
Tissue bank A place where tissue samples from patients are safely stored, and used by scientists to study diseases such as breast cancer.
TP53 gene A gene that provides instructions for making a protein called tumour protein p53. Some people inherit an altered TP53 gene, which can result in a rare inherited cancer syndrome called Li-Fraumeni syndrome. This can increase the risk of getting breast cancer.
TRAM (transverse rectus abdominis muscle) flap A type of breast reconstruction that uses the large muscle that runs from the lower ribs to the pelvic bone in the groin along with skin and fat.
Triple assessment An assessment to make a diagnosis of a benign breast condition or breast cancer. This has three parts:
- A breast examination
- Breast imaging (for example, a mammogram or an ultrasound scan)
- Tissue sampling (for example, a core biopsy or FNA)
Triple negative breast cancer The name given to breast cancer that is:
- Oestrogen receptor negative (ER-)
- Progesterone receptor negative (PR-)
- HER2 negative
TUG (transverse upper gracilis) flap or TMG (transverse myocutaneus gracilis) flap Types of breast reconstruction that use muscle from the inner or outer upper thigh along with skin and fat.
Tumour An overgrowth of cells forming a lump. May be benign (not cancer) or cancer.
Tumour markers Substances produced by cancer, or by the body as a response to cancer.
Tyverb see Lapatinib
Ultrasound scan A scan that uses high frequency sound waves to produce an image.
Vacuum assisted biopsy Used to remove breast tissue for examination under a microscope, often when a previous biopsy was difficult to perform or more tissue is needed to make a diagnosis. Sometimes it can be used as an alternative to surgery to remove a whole area of breast tissue (called a vacuum assisted excision biopsy).
Verzenio see Abemaciclib
Wide local excision (WLE) Surgery to remove breast cancer with a margin (border) of healthy tissue. Sometimes called breast-conserving surgery or lumpectomy.
X-ray Used to produce images of dense tissues in the body such as bone or lungs.
Xeloda see Capecitabine
Zoladex see Goserelin