Dr Robert Falconer is developing a new form of chemotherapy, which could only kill cancer cells, leaving healthy cells intact. If this project is successful, it could save lives and lead to more people living beyond breast cancer.
Dr Klaus Pors and his PhD student are investigating how to unlock the potential of chemotherapy drugs known as duocarmycins, which could provide a new, more effective treatment option for people with breast cancer – especially those whose cancer has returned or spread.
Prof Leonie Young is studying a protein called RET, which is thought to be involved in the spread of breast cancer to the brain. Her work could eventually lead to treatments which can control or even prevent secondary tumours in the brain.
Professor Richard Grose and Dr Ed Carter will study two types of cells involved in the progression of DCIS to invasive breast cancer. Understanding them better would help to predict which patients with DCIS will need treatment to stop invasive breast cancer developing.
Dr Timothy Humphrey is studying DNA modifications present in breast cancers, which could play a role in helping tumours to grow. His work could lead to new ways of treating breast cancers and ultimately save lives.
Dr John Maher is developing a new type of immunotherapy for breast cancer. In this project he is improving a CAR-T cell therapy so that it’s effective against breast cancer cells but doesn’t attack non-cancer cells, ensuring that the treatment is safe for testing in patients.