Dr Klaus Pors and his PhD student Josh Swadling are investigating how to unlock the potential of chemotherapy drugs known as duocarmycins, which could provide a new, more effective treatment option for people with breast cancer – especially those whose cancer has returned or spread.

 

Prof Leonie Young is studying a protein called RET, which is thought to be involved in the spread of breast cancer to the brain. Her work could eventually lead to treatments which can control or even prevent secondary tumours in the brain.

Dr Richard Grose and Dr Ed Carter will study two types of cells involved in the progression of DCIS to invasive breast cancer. Understanding them better would help to predict which patients with DCIS will need treatment to stop invasive breast cancer developing.

Dr Timothy Humphrey is studying DNA modifications present in breast cancers, which could play a role in helping tumours to grow. His work could lead to new ways of treating breast cancers and ultimately save lives.

Dr John Maher is developing a new type of immunotherapy for breast cancer. In this project he is improving a CAR-T cell therapy so that it’s effective against breast cancer cells but doesn’t attack non-cancer cells, ensuring that the treatment is safe for testing in patients.

We need better ways to track how secondary tumours in the bone respond to treatments. Professor Gary Cook is investigating whether a ‘tracer’ molecule can tell if these treatments are working at an earlier stage than is currently possible – and help patients live well for longer.