Professor Janet Brown wants to determine if combining an immunotherapy drug avelumab with another drug, radium-233, could make the treatment more effective. She hopes this combination will improve the immune response to secondary breast cancer in the bone and at other sites in the body.

Drugs that help the immune system to detect and destroy cancer cells show promise as a treatment for triple negative breast cancer. Dr Anne Armstrong will be running a trial to see whether giving aspirin alongside one of these drugs makes the treatment more effective at controlling tumours.

Dr Rebecca Beeken wants to see if a diet programme that has been beneficial in other diseases could also benefit overweight women with breast cancer.

It’s thought that turning on the androgen receptor in some oestrogen receptor positive (ER+) breast cancers could help stop tumour growth. Dr Violeta Serra is investigating this theory further and is testing whether the androgen receptor could be a new treatment target.

Palbociclib is a drug given to people with secondary, oestrogen receptor positive (ER+) breast cancer to help manage their disease. Dr Saskia Wilting is trying to find out who will benefit from taking this drug and why some cancers do not respond to it.

Professor Aleix Prat is investigating why some oestrogen receptor positive (ER+) breast cancers become resistant to treatment. He is looking at whether combining drugs could enhance treatment effectiveness, giving people the best possible chance of survival.