#ER+ #HER2- #HormoneTherapy
Help researchers who are hoping to see if a blood test can detect breast cancer recurrence early by looking for cancer DNA in the blood.
What's the title of the project?
TRAK-ER: A clinical trial to detect and treat molecular relapse of breast cancer
What's the project about?
TRAK-ER is a clinical trial is looking to see if a new blood test could help identify patients who are at a higher risk of their cancer returning. This works by looking for cancer DNA in the blood, which sometimes can be detected several months to years before secondary can be seen on a scan.
The researchers are also testing whether treatment with palbociclib and fulvestrant is more effective at preventing cancer recurrence than standard hormone therapies for who have had oestrogen receptor positive and HER2 negative breast cancer (ER+ HER2- breast cancer).
In the study, you will have your blood tested every three months for three years. This is to look for cancer DNA to see if it has come back. If cancer DNA is detected, you will have a scan to see if the cancer has come back. If no evidence of cancer is seen on the scan, you will enter the treatment part of the study.
In the treatment part of the study, you will either continue to receive standard hormone therapies, or they will receive a combination of two drugs called pablociclib and fulvestrant. The researchers will then look to see if patients treated with palbociclib and fulvestrant are less likely to have a recurrence compared to people receiving standard hormone therapies.
Who's organising it?
Name of individuals: Professor Nick Turner
Name of organisation: The Royal Marsden Hospital
More info: https://www.royalmarsden.nhs.uk/trak-er
What are the criteria for taking part?
Please read the website for full details on the study to see if it is right for you. This study is for people who have had oestrogen receptor positive and HER2 negative breast cancer (ER+ HER2- breast cancer) who have previously undergone surgery to remove the tumour in the breast. It is only for people who are taking hormone therapy to reduce the risk of the cancer coming back.
What do I need to do?
If you are interested, then you should ask your oncologist to make a referral to one of the cancer centres that is running TRAK-ER.
When's the deadline?
This project is ongoing
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