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1. What is inflammatory breast cancer?
2. What are the signs and symptoms of inflammatory breast cancer?
3. How is inflammatory breast cancer diagnosed?
4. How is inflammatory breast cancer treated?
5. Further support
Inflammatory breast cancer is a rare, fast-growing type of breast cancer. It is called inflammatory because the skin of the breast usually looks red and inflamed. This is caused by the breast cancer cells blocking the tiny lymph channels in the breast and the skin. The lymph channels are part of the lymphatic system.
The symptoms of inflammatory breast cancer can develop quite quickly. A lump may or may not be present. Symptoms can include:
Inflammatory breast cancer is sometimes difficult to diagnose. This is because the symptoms are similar to some benign (not cancer) conditions such as mastitis (breast infection) or a breast abscess, which are usually treated with antibiotics.
If you are prescribed antibiotics but your symptoms don’t improve you will be referred to a breast clinic where you may have several tests including:
For more information see What to expect at a breast clinic appointment.
If you are diagnosed with inflammatory breast cancer you may have further tests to check whether the cancer has spread outside the breast. These may include:
If you need to have any of these tests, your treatment team will explain more about them. You can also contact Breast Cancer Now’s free Helpline on 0808 800 6000 to talk this through, or to find out more information.
If you are diagnosed with inflammatory breast cancer, your treatment team will discuss your treatment options with you and prepare a treatment plan. The plan will be based on your test results.
Because inflammatory breast cancer can develop quite quickly, treatment is usually started as soon as possible. Treatment usually involves treating the whole body with drugs (systemic treatment) as well as the affected breast and the area around it (local treatment).
A combination of chemotherapy, surgery, radiotherapy, targeted (biological) therapy, hormone (endocrine) therapy and bisphosphonates may be used depending on your individual situation.
Chemotherapy is treatment using anti-cancer (also called cytotoxic) drugs to destroy cancer cells. It is usually the first treatment recommended for inflammatory breast cancer, before any surgery. This is called primary or neo-adjuvant chemotherapy.
Chemotherapy is given to treat and reduce the size of the cancer in the breast and to try to destroy any cancer cells that may have spread elsewhere in the body.
Find out more about chemotherapy »
Following chemotherapy, most people will have surgery. Usually the whole breast is removed including the nipple area (mastectomy). Your surgeon will normally remove the lymph glands from under your arm (axilla) at the same time.
If you’re able to have breast reconstruction following a mastectomy, this is more likely to be offered when you have completed all your treatment. This is called delayed breast reconstruction.
Radiotherapy uses carefully measured and controlled high energy x-rays to destroy any remaining cancer cells. It’s often used after chemotherapy and surgery to treat inflammatory breast cancer. You will usually have treatment to the whole breast area, and the area above your collarbone (clavicle). You may also have treatment to under your arm (axilla) and occasionally to the lymph nodes behind the breastbone (sternum).
Find out more about radiotherapy »
This is a group of drugs that block the growth and spread of cancer. They target and interfere with processes in the cells that help cancer grow.
The type of targeted therapy you are given will depend on the features of your breast cancer.
The most widely used targeted therapies are for HER2 positive breast cancer. HER2 is a protein that helps cancer cells grow.
Find out about targeted therapies »
Some breast cancers use oestrogen in the body to help them to grow. These are known as oestrogen receptor positive or ER+ breast cancers.
Hormone therapies block or stop the effect of oestrogen on breast cancer cells. Different hormone therapy drugs do this in different ways.
Hormone therapy will only be prescribed if your breast cancer is ER+.
Find out more about hormone therapy »
Bisphosphonates are a group of drugs that can reduce the risk of breast cancer spreading in post-menopausal women.
Find out more about bisphosphonates »
Clinical trials are research studies that aim to improve treatment or care for patients. Studies into treatments for inflammatory breast cancer are ongoing. This is something you can discuss with your treatment team, so you can decide what’s best for you.
Read more general information about clinical trials, or visit the Cancer Research UK website for listings of current UK trials.
Being diagnosed with inflammatory breast cancer can be a difficult and frightening time.
There may be times when you feel alone or isolated, particularly as inflammatory breast cancer is a rare type of breast cancer. There are people who can support you so don’t be afraid to ask for help if you need it.
Some people find it helpful to discuss their feelings and concerns with their breast care nurse or specialist. If you’d like to talk through how you are feeling in more depth, you may want to see a counsellor or psychologist. Your breast care nurse, specialist or GP can arrange this.
You can also call Breast Cancer Now’s Helpline on 0808 800 6000 and talk through your diagnosis, treatment and how you are feeling with one of our team.