Tamoxifen is a hormone (endocrine) therapy drug.
Tamoxifen is used to treat breast cancer in both premenopausal women (women who have not yet gone through the menopause) and postmenopausal women. It can also be taken by men who have breast cancer.
Some breast cancers use oestrogen in the body to help them to grow. These are known as oestrogen receptor positive or ER+ breast cancers.
Tamoxifen works by reducing the amount of oestrogen made in the body.
Find out more about hormone receptors and breast cancer.
Tamoxifen and coronavirus (Covid-19)
Taking tamoxifen does not affect your risk of getting coronavirus or of becoming seriously ill if you do get it.
It’s also safe to have a coronavirus vaccine while taking tamoxifen.
Primary breast cancer
Tamoxifen may be prescribed if you have primary breast cancer.
It’s usually given after surgery to reduce the risk of breast cancer returning in the same breast or spreading somewhere else in the body. This is known as adjuvant (additional) therapy.
Occasionally, tamoxifen may be used as the first treatment for breast cancer. This may be when surgery is not appropriate or needs to be delayed.
It’s sometimes given before surgery (known as neo-adjuvant or primary therapy) to shrink a larger breast cancer.
For people diagnosed with an early type of breast cancer called ductal carcinoma in situ (DCIS) the benefits of tamoxifen are less clear. Some evidence suggests that taking tamoxifen after surgery for DCIS reduces the risk of breast cancer coming back in the same breast and a new breast cancer developing on either side. Your specialist will discuss whether they feel it would benefit you.
Breast cancer that has come back or spread
Tamoxifen can also be used to treat people who have:
To reduce the risk of breast cancer developing
Tamoxifen may be an option for some people who do not have breast cancer but higher risk of developing it because of their family history.
Tamoxifen is taken as a tablet.
Occasionally it may be prescribed as a liquid for people who have difficulty swallowing.
The recommended dose for most people is 20mg daily.
It’s best to take it at the same time every day.
If you miss a dose, you don’t need to take an extra one the next day. The level of the drug in your body will remain high enough from the previous day.
Some versions of tamoxifen contain small amounts of lactose. If you know you are lactose intolerant discuss this with your treatment team or pharmacist.
The recommended length of time that tamoxifen is taken for will vary according to individual situations.
People being treated for primary breast cancer will usually take tamoxifen for between five and ten years.
If you become postmenopausal while taking tamoxifen, your treatment team may recommend you change from tamoxifen to a different hormone therapy known as an aromatase inhibitor. This can happen after two to three years of taking tamoxifen, or after you have taken tamoxifen for five years.
Sometimes tamoxifen is recommended after taking an aromatase inhibitor.
For younger women who are premenopausal, tamoxifen may be given alone or sometimes alongside ovarian suppression.
If you’re taking tamoxifen for locally advanced breast cancer or for secondary breast cancer, you’ll usually continue to take it for as long as it is keeping the cancer under control.
If you have a significant family history and are taking tamoxifen to reduce your risk of breast cancer developing, you’ll usually take it for five years.
Your treatment team will tell you when to stop taking tamoxifen. You won’t need to stop taking it gradually.
If, for any reason, you want to stop taking tamoxifen before the recommended time, talk to your specialist first. This is because not taking the drug for the recommended time may increase your risk of the breast cancer coming back or progressing.
Like any drug, tamoxifen can cause side effects. Everyone reacts differently to drugs. Some people will have more side effects than others, while others don’t experience any side effects at all. Having few or no side effects does not mean the drug is not effective.
If you’re concerned about any side effects, regardless of whether they’re listed here, tell your treatment team
Some people say they notice a change in the side effects they experience if they take tamoxifen made by a different manufacturer. This suggests that some people find tamoxifen produced by one manufacturer seems to suit them better than another.
You can discuss this with your treatment team or GP, or ask the pharmacist who dispenses your prescriptions if they can supply you with tamoxifen from the manufacturer you feel suits you the best.
Common side effects
The most common side effects of tamoxifen are menopausal symptoms such as:
- Hot flushes
- Night sweats and sleep disturbance
- Vaginal irritation such as dryness and itching
- Loss of sex drive
- Mood changes
Vaginal discharge is common when taking tamoxifen.
If you are worried about this, let your treatment or GP know so they can rule out an infection.
Effects on periods
Women who are still having regular periods may find that their periods change. For example, they may be lighter, irregular or they may stop altogether.
This may also be because the menopause has occurred naturally during this time or because other treatment such as chemotherapy has caused an earlier menopause.
Sometimes periods may return after you stop taking tamoxifen.
Tamoxifen can sometimes cause fluid retention, which may affect your weight.
Some women put on weight during treatment, although there is no clear evidence linking weight gain to tamoxifen.
Indigestion or nausea
Some people have indigestion or mild nausea (feeling sick). This is usually most noticeable when they start taking tamoxifen.
These symptoms generally improve or become easier to manage over time and may be helped by taking the tamoxifen with food or taking it at a different time of day.
Effects on bone health
If you are postmenopausal there is evidence that tamoxifen slows down bone loss, reducing the risk of osteoporosis (thinning of the bone).
However, tamoxifen may slightly increase the risk of osteoporosis for premenopausal women. This is unlikely to lead to osteoporosis unless treatment has been given to stop the ovaries from working as well.
Cancer-related fatigue is extreme tiredness and exhaustion that doesn’t go away with rest or sleep. It can affect you physically and emotionally.
It’s a very common side effect of tamoxifen and may last for weeks or months after your treatment has finished.
You may develop a skin rash, itchy or dry skin while taking tamoxifen.
Your pharmacist, GP or treatment team can tell you what products you can use on your skin to help.
Less common side effects
Effects on the womb
Tamoxifen can affect the lining of the womb (uterus), known as the endometrium, which may become thickened.
If you have any unexpected vaginal bleeding or pain, tell your GP or treatment team.
In a few cases, use of tamoxifen in postmenopausal women may cause polyps or ovarian cysts or, even more rarely, cancer of the womb. There doesn’t appear to be an increased risk of this type of cancer in premenopausal women taking tamoxifen.
Change to hair or facial hair
Some women have some hair loss or hair thinning while taking tamoxifen.
A small number of women notice an increase in downy facial hair.
Changes to vision
There is a very slight risk of changes to your vision, including a slightly higher than usual risk of developing cataracts.
If you notice any changes to your vision, tell your GP or treatment team.
Changes to the liver
Tamoxifen can occasionally cause changes to how the liver works. These changes are usually very mild and unlikely to cause any symptoms.
Once you finish your treatment your liver will usually go back to normal.
Other possible side effects
Some women notice a change to their singing voice.
Other reported side effects include:
- Joint pains
- Difficulty concentrating
- Leg cramps at night
Are there different side effects for men?
Men can have similar side effects as women, such as hot flushes and headaches.
A number of small studies have also noted other side effects, such as decreased sex drive, though this usually recovers after tamoxifen treatment has ended.
People with breast cancer have a higher risk of blood clots. Their risk is higher because of the cancer itself and some treatments for breast cancer. If the cancer has spread to other parts of the body (secondary breast cancer), this also increases the risk.
Taking tamoxifen increases the risk of blood clots such as deep vein thrombosis (DVT).
People with a DVT are at risk of developing a pulmonary embolism (PE). This is when part of the blood clot breaks away and travels to the lung.
Blood clots can be harmful but are treatable so it’s important to report symptoms as soon as possible.
If you experience any of the following symptoms contact your local A&E department, GP or treatment team straight away:
- Pain, redness/discolouration, heat and swelling of the calf or thigh
- Swelling, redness or tenderness where a central line is inserted to give chemotherapy, for example in the arm, chest area or up into the neck
- Shortness of breath
- Pain or tightness in the chest
- Unexplained cough or coughing up blood
Find out more about blood clots.
People taking tamoxifen need to be aware of the risk of blood clots and ways to reduce this.
Long periods of inactivity can increase your risk of developing blood clots. If you’re planning a long-distance plane, car or train journey, you can get advice from your treatment team or GP.
If you need to have treatment or surgery that will reduce your mobility, discuss with your specialist whether you need to stop taking tamoxifen before and after this.
Can I take tamoxifen with other drugs?
Always check with your treatment team or pharmacist if you’re taking any other medicines with tamoxifen.
A few studies have suggested that some drugs may interfere with the way tamoxifen works, making it less effective. These include fluoxetine (Prozac), paroxetine (Seroxat), bupropion (Wellbutrin, Zyban, Voxra, Budeprion or Aplenzin), quinidine (Quinidine Gluconate or Quinidine Sulfate) or cinacalcet (Sensipar).
More recent research suggests this is unlikely, but you may be recommended not to use these drugs with tamoxifen, in which case an alternative may be suggested.
Check with your treatment team before stopping taking these drugs as stopping them suddenly may be harmful.
Herbal medicines and supplements
Many people consider taking herbal products or supplements while having treatment for breast cancer. However, the exact effect and safety of taking these after a diagnosis of breast cancer is not fully understood. Ask your treatment team or pharmacist before taking herbal products or supplements.
Contraception while taking tamoxifen
Taking tamoxifen while pregnant may be harmful to a developing baby. It’s possible to become pregnant while taking tamoxifen even if your periods have become irregular or stopped.
If you’re sexually active with a chance of becoming pregnant, your specialist is likely to advise you use a non-hormonal method of contraception while taking tamoxifen and for two months after stopping. Non-hormonal methods include condoms, Femidoms or a diaphragm
It may also be possible to use a coil (IUD or intrauterine device). However, you would need to discuss this with your treatment team as not all types are suitable for women with breast cancer.
If you think you may be pregnant, tell your specialist as soon as possible.
Fertility, pregnancy and tamoxifen
In most premenopausal women who take tamoxifen, the ovaries continue to work. When you start taking tamoxifen it may stimulate the release of an egg from the ovary (ovulation) and could make you more fertile. However, getting pregnant is not recommended (see ‘Contraception while taking tamoxifen’ above).
For some women, continued use of tamoxifen means periods become less regular, lighter or stop altogether.
Generally, your periods will start again once you stop taking tamoxifen, as long as you have not gone through the menopause naturally while taking the drug. It may take four to five months for your periods to become regular again.
Because of the length of time tamoxifen is taken for, the side effects may hide the signs of a natural menopause. It may only be when you finish taking it that you realise you have started your menopause.
If you want to have children and you’re in your 30s or early 40s, taking hormone treatment for five years or more may be a concern you want to discuss with your treatment team.
If you’re planning to get pregnant after you have finished taking tamoxifen, it’s advisable to wait at least two months to allow time for the drug to leave the body completely. Talk to your treatment team about the most appropriate length of time for you.
Find out more about fertility and breast cancer treatment.
Tamoxifen and breastfeeding
Women taking tamoxifen are advised not to breastfeed as it may pass through the bloodstream into the breast milk.
Being diagnosed with breast cancer can make you feel lonely and isolated.
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